负荷后1小时血糖水平升高与动脉硬化度增加
研究通讯/ResearchLetter
JournalofDiabetes9()-
负荷后1小时血糖水平升高与动脉硬化度增加相关
Elevated1-hpost-challengeglucoselevelsassociatedwithincreasedarterialstiffness
TsugumichiSAITO,1KatsuraNIIJIMA,2EijiroYAMADA,1YawaraNIIJIMA,2ShuichiOKADA1andMasanobuYAMADA1
1DepartmentofMedicineandMolecularScience,GunmaUniversityGraduateSchoolofMedicine,and2Kan-etsuChuoHospital,Gunma,Japan
在既往的一项对糖耐量正常人群的横断面研究中,我们报道了臂踝脉搏波速度(brachial–anklepulsewavevelocity,baPWV),一个测量动脉硬化的指标,与负荷后1小时血糖水平相关。此外,发现负荷后1小时血糖水平≥mg/dL的亚组人群(对应于以餐后2小时血糖判定的糖耐量受损)有动脉硬化,其baPWV值更高,但空腹血糖和餐后2小时血糖处于正常值范围内。这些发现表明糖耐量正常的人群当其负荷后1小时血糖水平由正常转为高于正常时,就会出现动脉硬化。
Inapreviouscross-sectionalstudyinvolvingsubjectswithnormalglucosetolerance(NGT),wereportedapositivecorrelationbetweenbrachial–anklepulsewavevelocity(baPWV),ameasureofarterialstiffness),and1-hpost-challengeglucose(PG).[1]Furthermore,thesubpopulationofNGTsubjectsdefinedby1-hPG≥?mg/dL(correspondingtoimpairedglucosetolerance,asdeterminedwitha2-hPG)exhibitedarterialstiffness,asevidencedbyhigherbaPWVvaluesdespitefastingplasmaglucose(FPG)and2-hPGvaluesbeingwithinthenormalrange.[1]ThesefindingssuggestthatifNGTsubjectsconverttohigher1-hPGlevelsfromanormal1-hPGrange,theywilldeveloparterialstiffness.
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JournalofDiabetes(主编:宁光(中国),ZacharyT.Bloomgarden(美国))主办,记录糖尿病临床研究的足迹,推进中国逾亿位糖尿病患者的诊治!
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